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Iwamoto et al

In GHRH knockout murine models, CJC-1295 administered daily was associated with normalization of body weight, bone growth (femur, tibia), and pituitary GH mRNA levels

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Although this modification was instigated given a predominance of CNS relapse observed, hyperglycemia appeared to be the main toxicity that could be attributed to GC, while the remaining side effect profile appeared to be more related to asparaginase